News & publications
Latest updates from QUANTRO
Read verified company announcements, collaboration updates and the peer-reviewed research behind QUANTRO’s time-resolved transcriptomics platform.
Press releases
Company announcements
QUANTRO Therapeutics extends collaboration with Boehringer Ingelheim to address high unmet needs in cancer patients
The collaboration was extended for two additional years following the successful completion of a major high-throughput screening campaign and the identification of attractive hits for further development.
QUANTRO Therapeutics achieves breakthrough in transcriptomic drug discovery with first successful simultaneous 10-target multiplex-screening
The first-ever simultaneous 10-target multiplexing high-throughput screen met all quality control criteria, achieved a 100% hit rate for both positive and negative controls, and identified high-quality hits across most of the selected targets.
QUANTRO Therapeutics and IMP enter into research collaboration to accelerate transcriptomic drug discovery
A strategic research collaboration with the group of Dr. Johannes Zuber at the Research Institute of Molecular Pathology to investigate the molecular functions of transcription factor complexes.
QUANTRO Therapeutics secures important Austrian research grant to accelerate development of cutting-edge platform
The Austrian Research Promotion Agency FFG awarded an 18-month grant in support of a EUR 1.7 million R&D project, catalysing the scale-up and multi-target profiling capability of QUANTRO’s platform to industrial level.
Publications
The peer-reviewed science behind the platform
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2017Foundational method
Thiol-linked alkylation of RNA to assess expression dynamics
Herzog VA, Reichholf B, Neumann T, et al. Nature Methods. 2017;14(12):1198–1204. DOI: 10.1038/nmeth.4435.
This study established SLAMseq®, using 4-thiouridine labelling and thiol-linked alkylation to distinguish newly synthesised RNA from pre-existing RNA in standard sequencing data.
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2018Direct gene-regulatory functions
SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis
Muhar M, Ebert A, Neumann T, et al. Science. 2018;360(6390):800–805. DOI: 10.1126/science.aao2793.
This study combined SLAM-seq with acute perturbation to distinguish the direct transcriptional programmes of BRD4 and MYC from downstream and adaptive effects.